Expérimental
The proposed internship delves into mechanobiology, exploring the influence of mechanical forces generated by cells on biological tissue formation, organization, and function, with a specific focus on nematic-like tissues, such as muscles. The study aims to understand the role of physical constraints in muscle cell differentiation, offering insights into muscular pathologies. The project introduces an innovative approach using magnetic nanoparticles to render cells magnetic, enabling remote manipulation , facilitating the creation of controlled 3D cellular tissues. The research investigates the impact of mechanical stimuli on these micro-tissues and explores the possibility of manipulating muscle fiber types through stimulus modulation.