Expérimental et théorique
mRNA vaccines development is undoubtedly one of the most promising medical fields - as underlined by the 2023 medicine Nobel prize. Following our earlier work performed with a Sanofi iAward 2021 grant, we propose to improve the efficiency of mRNA vaccine development and consequently the quality of the resulting vaccines using a novel, biophysics-based-methodology (single-molecule force measurements with optical traps), which allows to investigate mRNA structure with high precision. The student will be in charge of single-molecule force measurements and data analysis of one such mRNA vaccine candidate. These investigations can be carried on and extended during a subsequent PhD thesis.