In this topic, we will utilize extensive imaging spectroscopy datasets of galaxies in the local universe, such as M83, to study a large number of giant molecular clouds (GMCs). GMCs are considered the birthplace of massive stars within galaxies. Our investigation will focus on the physical and chemical properties of GMCs using rich ALMA imaging spectroscopy data sets of various molecular lines to understand the underlying physical processes that govern their evolution. This, in turn, will provide insights into the regulatory mechanisms affecting the overall evolution of galaxies.