Neural crest cells (NCCs) are a population of totipotent, highly migratory cells common to all vertebrates. They colonize developing embryonic tissues to form a wide range of derivatives: the adrenal gland, bones (ear, jaw), Schwann cells (myelin) of the peripheral nervous system, melanocytes (skin pigments), and the enteric nervous system (intrinsic innervation of the intestine). Migration defects give rise to more than 20 different syndromes known as neurocristopathies, that lead to severe intestinal, cranio-facial, nervous, cardiac or skin impairements. At MSC, we have discovered that spontaneous electrical calcium activity underpins neural crest cell migration. This internship aims at deciphering the link between this spontaneous electrical activity and cellular force generation that drives cell migration, by performing traction force microscopy, cell membrane tension, and galvanotaxis experiments.